Boston RISE Study Inclusion/Exclusion Criteria

The inclusion criteria for this study are:

  1. Age ≥65 years
  2. Able to understand and communicate in English
  3. Difficulty or task modification with mile (6 blocks) or climbing one flight of stairs

The exclusion criteria for this study are:

  1. Presence of a terminal disease (e.g. receiving hospice services, metastatic cancer)
  2. Major surgery or Myocardial Infarction in the last 6 months
  3. Planned major surgery (e.g. joint replacement)
  4. Planned move from the Boston area within 2 years
  5. Baseline Mini-mental state exam (MMSE) score <18
  6. Major medical problems interfering with safe and successful testing (examples may include: history hip replacement with recurrent dislocation, uncontrolled hypertension, use of supplemental oxygen)
  7. Baseline Short Physical Performance Battery (SPPB) score <4

Initial eligibility will be determined via a telephone interview, which will review inclusion criteria and all exclusion criteria except items 5 & 7.

Potential subjects must demonstrate self reported task modification on a brief questionnaire developed by Fried and colleagues. This measure of preclinical disability, evaluating the ability to walk ½ mile or climb one flight of stairs is a valid predictor of incident mobility related disability at 18 months. It was developed specifically for screening older adults as we are proposing.

Potential subjects will be invited to the MGH Clinical Research Center (CRC), to complete consenting and undergo a screening physical exam that will screen for the remaining exclusion criteria such as the MMSE and the SPPB. The MMSE will be administered and those who score <18 on the test will be excluded from the study. The cut point was chosen because it is valid for dementia screening in low income and minority populations. SPPB scores <4 would be consistent with individuals who are currently disabled and within whom subsequent decline would make compliance with the study procedures less likely. Enrolled subjects who develop medical status changes consistent with exclusion criteria will remain in the study. However, a 12- and/or 24-month assessment procedures may be abbreviated or not performed based upon the corresponding safety concerns and the availability/need for proxy respondents. Eligible individuals will be scheduled for the baseline assessments.